 오퍼게시판 |
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제 목:
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Gliclazide |
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등록분류: |
Offer to Sell |
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내용: |
CAS NO: 21187-98-4
Additional_detail: Gliclazide (21187-98-4) is an oral antihyperglycemic agent used for the treatment of diabetes mellitus type II. It belongs to the sulfonylurea class of insulin secretagogues, which stimulates β cells of the pancreas to release insulin. Gliclazide binds to the β cell sulfonyl urea receptor (SUR1), further blocking the ATP sensitive potassium channels. Therefore, the potassium efflux substantially decreases, causing depolarization of the β cells. Then the voltage-dependent calcium channels in the β cell are open, resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretory granules. Recent studies have also shown that gliclazide can effectively improve anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes and protect pancreatic beta-cells from damage by hydrogen peroxide.
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연락처 |
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당 자: |
Xie Wen Feng |
| 회사주소: |
16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China |
| 전화번호: |
+86-592-5881089 |
| 팩스번호:
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+86-592-5854960 |
| E - mail: |
xie@china-sinoway.com |
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